Lakehead University: Department of Biology: Dr. John Th'ng

Adjunct Professor

Career Scientist

Contact

Office: (807) 343-8460
Email: jthng@lakeheadu.ca or John.Thng@normed.ca

Research Interests

Histone modifications and their roles in regulating chromatin structure and gene expression. Expression of cell cycle proteins and their effects on cell division.

Selected Publications

Matthew, J., Kaskiw, M.J., Tassotto, M.L., Th'ng, J., and Jiang, Z.-H. (2008). Synthesis and cytotoxic activity of diosgenyl saponin analogues. Bioorg. Med. Chem. Epub ahead of print

Chen, J., Halappanavar, S., Th'ng, J.P.H., and Li, Q. (2007). Ubiquitin-dependent distribution of the transcriptional coactivator p300 in cytoplasmic inclusion bodies. Epigenetics. 2: 92-103.

Richard, C., W. Duivenvoorden, D. Bourbeau, B. Massie, W. Roa, J. Yau, Th'ng, J.P.H. (2007). Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy. Cancer Gene Ther. 14, 57-65.

Rundle, N.T., J. Nelson, Flory, M.R., Joseph, J., J. Th'ng, R. Aebersold, M. Dasso, R.J. Andersen, M. Roberge. (2006). An ent-kaurene that inhibits mitotic chromosome movement and binds the kinetochore protein ran-binding protein 2. ACS Chem. Biol. 2006 Aug. 22; 1(7): 443-450.

Richard, D., Yau, J., Th'ng, J.P.H., and Duivenvoorden, W. (2006). Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents. Clin. Exper. Metast. 23, 249-258.

Th'ng, J.P.H., Sung, R., Ye, M., and Hendzel, J.J. (2005). H1 family histones in the nucleus: control of binding and localization by the C-terminal domain. J. Biol. Chem. 280, 27809-27814.